Chair andC hief Executive, NantWorks

As a physician, South African-born Soon-Shiong developed therapies for diabetes and cancer including Abraxane, which is used for the treatment of metastatic breast cancer, lung cancer and advanced pancreatic cancer. He made his fortune selling two companies he started: the $4.6 billion sale of generic drug company APP Pharmaceuticals in 2008 and the $3.8 billion sale of Abraxis Bioscience in 2010. His immunotherapy company, ImmunityBio Inc., announced last year it would submit its first biologic drug to the Food and Drug Administration for evaluation. Soon-Shiong topped the Business Journal’s 2022 list of Wealthiest Angelenos with a net worth of $19.1 billion.

YEARS ON THE LA500: 8