RadNet Inc. has become one of the first – and largest – operators of medical imaging centers to offer a cutting-edge test for brain abnormalities linked to Alzheimer’s disease. The new scan opens a potentially lucrative product line for the L.A. company.
The abnormalities, called Amyloid plaques, are a sticky protein buildup long considered a reliable indicator of Alzheimer’s. The new test involves injecting a radioactive tracer called Amyvid, which Eli Lilly & Co. of Indianapolis developed in conjunction with its experimental treatments for the disease.
Amyvid, which received U.S. regulatory approval in May, makes it easier for radiologists to detect the plaques when reviewing digital images from a positron emission tomography/computed tomography machine, better known as a PET/CT scan.
While there are risks to undergoing a PET scan using a radioactive tracer, the procedure is considered considerably safer than undergoing a brain biopsy that could cause brain damage.
“This was a truly unique opportunity for us,” said Dr. Judith Rose, RadNet’s director of PET/CT and nuclear medicine.
Because there are so few radioactive tracers approved by the Food and Drug Administration, the company’s PET/CT machines, which can cost up to $2.5 million each, often don’t get as much use as they could. The machines are mostly used for diagnosis of certain cancers and a limited number of neurological conditions.
RadNet has begun rolling out the Amyvid scans at six centers in Southern California, one in Northern California and three on the East Coast. Its centers in Encino and Thousand Oaks are scheduled to run their first scans this week, with scans tentatively scheduled for next week at its Beverly Hills office.
There is no cure for Alzheimer’s disease, which afflicts 5.4 million people in the United States and is the nation’s sixth largest cause of death among adults. There also are no drugs on the market that prevent or slow the progression of Alzheimer’s, the most common form of dementia. But RadNet foresees several markets for the test while treatments are being developed.
Rose said one drug developer working on an Alzheimer’s treatment already has agreed to send clinical trial patients to RadNet facilities and the company expects several more partnerships.
There also is value for patients who might have similar diseases, such as vascular dementia, to be able to rule out Alzheimer’s because the treatment approaches can vary widely. About 20 percent of Alzheimer’s cases later turn out to have been misdiagnosed, Rose said.
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