The Dow Jones industrial average rose 64 points in Wednesday trading to close at 18,076.

The S&P 500 rose four points to 2,114.

The Nasdaq rose 23 points to 5,099.

The LABJ Stock Index rose one point to 233.

Gainers and Losers

Wednesday’s biggest local gainer was Sylmar’s Second Sight Medical Products Inc., the maker of an artificial retina for blind patients. Shares rose six percent on the day, closing at $14.58 hours. Earlier in the day, the company announced it had appointed MannKind Corp. Chief Financial Officer Matthew J. Pfeffer to its board.

Wednesday’s biggest loser was agricultural biotech Ceres Inc. The Thousand Oaks company’s shares fell three percent on the day, closing at $2.13, a week after the the announcement of a new patent sent the stock soaring.