The Dow Jones industrial average fell 49 points in Wednesday trading to close at 17,169.

The S&P 500 fell 12 points to 2,019.

The Nasdaq fell 41 points to 4,840.

The LABJ Stock Index fell one point to 232.

Gainers and Losers

Carson online parts retailer U.S. Auto Parts Network Inc. was Wednesday’s biggest local gainer among stocks trading above $1. Shares rose 6 percent on the day, closing at $2.08.

Wednesday’s biggest loser was Pasadena biotechnology company Arrowhead Research Corp. Shares fell 6 percent on the day, closing at $4.90.