The Los Angeles Business Journal’s index of the largest local public companies fell for the week. The weighted LABJ index lost less than two percent to close at 222 with losers outpacing gainers 98 to 51. Eight companies closed the week unchanged.

Kythera Biopharmaceuticals in Westlake Village had a good week, with shares rising 28 percent to close at $53. Documents released this week by a FDA panel indicate the agency will likely approve a Kythera drug used to reduce the appearance of double-chin.

Medbox Inc., a West Hollywood maker of marijuana dispensing machines, saw its shares rise 19 percent to close the week at $2.16 after investment firm Lizada Capital signed a deal Wednesday to become Medbox’s largest shareholder.

Santa Monica-based TrueCar was one of this week’s losing stocks. Shares fell 15 percent to close the week at $16.84.