The Los Angeles Business Journal’s index of the largest local public companies closed down for the week ended April 30 as investors reacted to disappointing economic and earnings reports.

The weighted LABJ index closed down 2 percent to 121.75, with decliners outpacing gainers 114 to 68.

Among the largest decliners was Los Angeles community bank Pacific Commerce Bank, which fell 20 percent to $4 after reporting higher quarterly earnings in the first quarter but an increase in non-performing loans.

OSI Systems Inc. likewise took a fall after a mixed fiscal third quarter report. The Hawthorne imaging systems maker reported higher profits, largely due to security scanning revenue, but a decline in sales of its medical systems.

Calabasas casual dining chain Cheesecake Factory Inc. lost nearly 11 percent to $27.17 as the restaurant sector took a hit on disappointing sales reports at other companies.

Among the top gainers was Power-One Inc., which jumped 42 percent to $8.86 after the Camarillo maker of energy conversion devices announced higher-than-expected first quarter profits on strong sales of its products for solar and wind energy installations.

Valencia’s MannKind Corp. rose 11 percent to $6.95 after reporting a smaller first-quarter due to lower spending on its inhaled insulin drug candidate Afrezza, which is awaiting regulatory approval. It also got a boost from new studies about the drug’s safety.