Capping more than a year of negotiations, Los Angeles Mayor Antonio Villaraigosa on Thursday signed into law the Clean Trucks Program, the port proposal that will fund the replacement of diesel trucks with cleaner burning models.

The $2.2 billion program is set to begin Oct. 1 by restricting all pre-1989 trucks from the harbor.

“Los Angeles has said, ‘enough is enough.’ When 1,200 lives are cut short every year by toxic emissions coming from the port, we have a moral mandate to act fast and effectively,” Villaraigosa said in a statement. “That is why I am signing into law the cornerstone segment of the world’s most comprehensive, sustainable plan to clean up a major port.”

The clean air program will reduce diesel truck emissions at the port by 80 percent, officials say.

Under the controversial program, motor carriers will be restricted from using independent contract drivers and must hire employees to operate company vehicles.

The trucking industry has objected to the plan, saying it will drive up costs and allow unions to organize drivers. The American Trucking Association has repeatedly said it will file a lawsuit to block the program.

The Port of Long Beach rejected the employee provision.