The Los Angeles Business Journal’s index of the largest local public companies rose for the week. The weighted LABJ index climbed 2 percent to close at 235, with gainers outpacing losers 94 to 59. Five companies closed the week unchanged.

Among stocks trading above $1, Kythera Biopharmaceuticals Inc. was by far the week’s biggest gainer. Shares rose 37 percent to close at $75 on Friday. Shares spiked after Irish pharmaceutical giant Allergan announced Wednesday it would buy the Westlake Village company for $2.1 billion.

Cadiz Inc. was another winner this week, with shares of the downtown Los Angeles water storage company climbing 27 percent to close at $9.77 after controlling shareholder Stellar Capital Partners made a takeover offer.

Woodland Hills biotechnology company Lion Biotechnologies Inc., which develops cancer immunotherapies, was one of the biggest losers for the week, with shares falling 12 percent to close Friday at $9.76.