The Los Angeles Business Journal’s index of largest local public companies closed down slightly for the week.

The weighted LABJ Stock Index closed down 0.23 percent to 175.97 for the trading week ended Nov. 29. Gainers outpaced decliners 97 to 57, with eight companies unchanged.

Drug developers were among the week’s biggest gainers, benefiting from positive analyst reports about the sector. Immunocellular Therapeutics of Woodland Hills jumped 27 percent to $3.31 and CytRx Corp. of West L.A gained 17 percent to $2.47. Arrowhead Research Corp. rose 12 percent to $8.23 and Puma Biotechnology of Westwood added 11 percent to $49.79.

AeroVironment Inc. rose 11 percent to $30.17. The Monrovia maker of unmanned drone aircraft and electric car battery chargers gave a brighter outlook, despite an 80 percent profit decline in its fiscal second quarter.

Among the biggest decliners was Ceres Inc., falling 8 percent to $1.62. The Thousand Oaks energy crop company continued to suffer from a worse-than-expected fiscal fourth quarter report.

Ixia fell 6 percent to $12.99. The Calabasas computer network equipment was warned by Nasdaq that it no longer complies with listing rules and had until Jan. 18 to submit a plan to regain compliance.