The Los Angeles Business Journal’s index of largest local public companies closed down for the week.

The weighted LABJ Stock Index fell 1.84 percent to 172.74 for the trading week ended Dec. 13. Decliners outpaced gainers 96 to 57, with seven companies unchanged.

The biggest mover was CytRx Corp. soaring 117 percent to $5.72. The West L.A. biotech announced positive results in a mid-stage clinical trial of its experimental cancer treatment aldoxorubicin.

The biggest decliner was ImmunoCellular Therapeutics Ltd., dropping 67 percent to $1.02. The Woodland Hills biotech announced disappointing results for mid-stage clinical trials of its experimental brain cancer drug ICT-107.

OSI Systems Inc. fell 15 percent to $64.75. Shares of the Hawthorne maker of security screening equipment continued to slide due to by the U.S. Transportation Security Administration cancellation of a $60 million order for airport baggage screening machines.

Puma Biotechnology Inc. gained for a second week, rising another 12 percent to $86.92. Shares of the West L.A. cancer drug developer continued to benefit from preliminary clinical trial results for its experimental breast cancer therapy neratinib.